Molecular Docking study of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein with Celastroid Triterpenoid Inhibitors

Severe acute respiratory syndrome coronavirus 2 poses a huge threat to humans. The β genus has four structural proteins: Spike, envelope, membrane and nucleocapsid protein. Among them, spike plays an important role in the host cell attachment fusion. S1 subunit of is responsible for bonding hence most crucial target finding appropriate inhibitors. Molecular docking calculations at receptor binding domain have been carried out with twenty celastroid triterpenoids found that they very good energies. interactions these compounds amino acid residues were also thoroughly investigated. further validated by farPPI web server.